WG3-Intact and top-down, novel fragmentation techniques

Marta Vilaseca, Edwin de Pauw

Deliverables:

– SOPs for top-down ETD fragmentation of proteins

– Evaluation of ETD for protein surface mapping

– ETD fragment spectra computational interpretation

– Theoretical model of ETD fragmentation process

– Evaluation of LID for top-down fragmentation

 

Collaboration with the Consortium for Top Down Proteomics