Working Group 5: MS in Biopharma

Meeting of Working Group 5: MS in Biopharma

 

Wednesday 13th July, Birkbeck College, London

 

The goal of this working group meeting is to discuss what is the role of structural proteomics methods in a Biopharma context (discovery/quality control), what are the current needs and/or bottlenecks? and whether there is a need for new methods / instrumentation to be developed. There will be a particular focus on discussion of potential solutions, as well as developing an EU-based framework for on-going collaborative work.

 

Format

 

The meeting will take place in round-table format, with four key topics to be considered in depth. Each topic will be kick-started by a 15 minute presentation by an invited speaker, who will then, together with a designated chair, lead the ensuing discussion.

 

Programme

 

Time Session Speaker
10:30 Tea and Coffee
11:00 Session 1 – Challenges in biopharma solved by MS Jonathan J Philips
12:15 Lunch
13:15 Session 2 – How critical is a critical attribute? Cianferani Sarah
14:30 Session 3 – The use of MS in biopharma – top down Derek Wilson
15:45 Coffee
16:00 Session 4 – The use of MS in biopharma bottom up Perdita Barran
17:15 Wrap up discussion
17:30 Refreshments

 

Attendees

 

Milena Quaglia – LGC

Cianferani Sarah – University of Strasbourg

Rachel Garlish – UCB

Jonathan J Philips – University of Cambridge

Derek Wilson – York University

Marta Vilaseca – IRB Barcelona

Justin Benesch – University of Oxford

Jonathan Hopper – University of Oxford

Edwin de Pauw – University off Liege

Johann Far – University off Liege

Nicolas Smargiasso – University off Liege

Claire Eyers – University of Liverpool

Perdita Barran – University of Manchester

Frank Sobott – University of Antwerp

Kostas Thalassinos -UCL

Kamila Pacholarz – University of Manchester

Zoja Nagurnaja – UCL

Sneha Chatterjee – University of Antwerp

 

 

 

Accommodation

 

There are plenty of hotels around Birkbeck. Some of the hotels that are recommended by the department are:

 

The Academy (Gower Street) (mid-range price) – https://www.theacademyhotel.co.uk

The Imperial Hotels (low price) – http://www.imperialhotels.co.uk/tavistock

Montague on The Gardens (Montague Street) (expensive) – http://www.montaguehotel.com/

The Morgan Hotel (Bloomsbury Street) (mid-range price) – http://www.morganhotel.co.uk/

 

Directions

 

The meeting will be in Room B04 which is in Birkbeck Main building at Torrington Square (building 1, on the attached map). Go to the main reception of Birkbeck and signs will guide you to B04 which is in the basement.

 

Travel to our central London campus by public transport

 

  • Birkbeck is surrounded by tube and mainline rail stations: we are close to Russell Square, Tottenham Court Road, King’s Cross and Euston – check our interactive map.
  • Many bus routes pass down nearby Gower Street or go via Russell Square. To plan your journey to Birkbeck using public transport, see the Transport for London Journey Planner.

 

 

Travel to our central London campus from the airport(s)

 

  • Those of you who are flying in to London Heathrow may wish to note that you can take the Underground (Piccadilly Line, East Bound) to King’s Cross or Russell Square from where you can take a taxi to Birkbeck.
  • For those flying in to Gatwick, we suggest you take the ‘Gatwick Express’ to Victoria Station, then take a taxi.
  • Planning your initial journey on arrival will depend largely where you will stay in London. Useful web sites include:

 

COST Action BM1403 Mini Symposium

On Wednesday morning, prior to the SSP conference, the COST Action BM1403 (Native Mass Spectrometry and Related Methods for Structural Biology) is organising a mini-symposium on topics relevant to the whole Structural Proteomics community, which is open to anyone to attend (SSP conference delegates welcome).

There will be a number of short talks from students and postdocs from within the COST group but importantly, the Working Group leaders will also report on inter-lab comparisons and recommended work practices for several key structural proteomics techniques.

 Venue

 

TU Main Building

Straße des 17. Juni 135

Lecture Hall H0110

Programme

8:50 Welcome

9:00 Valerie Gabelica, Bordeaux: Community standards and recommendations for ion mobility MS (WG1)

9:20 Kasper Rand, Copenhagen: Community standards and recommendations for HDX-MS (WG2)

9:40 Claudio Iacobucci, Halle/Saale: Evaluation of inter-lab comparison and recommendations for xlink-MS (WG2)

10:00 Justin Benesch & Kostas Thalassinos: Computational methods for native & ion mobility MS (WG4)

10:30 Coffee break

11:00 Esben Trabjerg, Zurich: Feasibility of succinimidyl-based crosslinking at slightly acidic conditions

11:20 Shane Chandler, Oxford: Coupling gas-phase HDX to IMS reveals structural transitions as proteins leave their native state

11:40 Jasmin Dülfer, Hamburg: HDX-MS of norovirus capsid proteins

12:00 tbc