PhD Research Fellowship in Structural Biology and Chromatin at University of Oslo (The Centre for Molecular Medicine Norway – NCMM)

A 3 year PhD fellowship is available in the Group for Chromatin and Structural Biology.

The Group for Structural Biology and Chromatin (Sekulic Group) investigates chromatin biology and epigenetics with a biochemical and structural approach. The project aims at understanding changes in chromatin during mitosis and kinetochore formation. We use various biochemical and biophysical approaches (X-ray crystallography, SAXS, SANS, hydrogen-deuterium exchange …). In addition, we collaborate with cell biology groups to link structure with function.

Sekulic group is affiliated with both the Faculty of Medicine and the Department of Chemistry at the Faculty of Mathematics and Natural Sciences. The PhD student will also benefit from career development programs offered both at UiO as well as the Nordic EMBL network of the Centre for Molecular Medicine, Norway.

PhD candidate: A three-year position is available immediately. We seek highly motivated individuals with an excellent track record and experience in protein purification and biophysical and biochemical characterization of proteins and protein complexes. Experience in the field of structural biology and mass spectrometry techniques is an advantage. We offer stimulating environment with excellent working and social benefits.

The purpose of the fellowship is research training leading to the successful completion of a PhD degree.

The fellowship requires admission to the PhD program at the Faculty of Mathematics and Natural Sciences. The application to the PhD program must be submitted to the department no later than two months after taking up the position. For more information see:

http://www.mn.uio.no/english/research/phd/

http://www.mn.uio.no/english/research/phd/application/application.html

The ideal candidate will have:

• A Master’s degree in biochemistry, chemistry, molecular biology or a related area

• Hands-on experience with purification of proteins and assembly of protein complexes

• Ability to independently perform experiments, analyze and interpret the results

• Excellent interpersonal/communication skills

• Excellent written and oral English

• Ability to operate as a team player in a multi-disciplinary environment

The application must include:

• Cover Letter stating motivation and research interests

• CV

• Copies of certificates and grades with explanation of the grading system

• A complete list of scientific publications

• List of references (name, relation to candidate, e-mail and telephone number)

Foreign applicants are advised to attach an explanation of their University’s grading system. Please remember that all documents should be submitted in English.

In accordance with the University of Oslo’s equal opportunities policy, we invite applications from all interested individuals regardless of gender or ethnicity.

UiO has an agreement for all employees, aiming to secure rights to research results a.o.  Note that no one can be appointed for more than one specified period at the same institution.

Salary: The position will be placed as SKO 1017 (position code) with salary depending on qualifications within step 50-57 (NOK 436 900 – 490 900  per year) depending on qualifications and seniority.

Inquiries:

About the position: Group Leader,  Nikolina Sekulic (nikolina.sekulic@biotek.uio.no).

About administrative aspects of the application: Nina Modahl (ninam@ncmm.uio.no).

Please submit your application through the web-based recruitment system  https://www.jobbnorge.no/apps/jobbadmin/Project/Applicants.aspx?jobid=144835

The University of Oslo is Norway’s oldest and highest ranked educational and research institution, with 28 000 students and 7000 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.

Centre for Molecular Medicine Norway (NCMM) was established in 2008 and is the Norwegian node in the Nordic EMBL Partnership for Molecular Medicine. NCMM is a joint venture between the University of Oslo, Health Region South-East and the Research Council of Norway. From 2017 NCMM is merged with the Biotechnology Centre of Oslo and now has altogether 11 research groups. The overall objective of NCMM is to conduct cutting edge research in molecular medicine and biotechnology as well as facilitate translation of discoveries in basic medical research into clinical practice.

Training School for Cross-Linking Vienna

Date: 23.10.2017, 9:00 am – 5.00 pm Location: IMBA, Dr. Bohrgasse 3, Lecture Hall

9.00 – 9.15 –Welcome (Frank Sobott, Karl Mechtler,)
9.15 – 10.00 Introduction about Cross-linking (Andrea Sinz, Alexander Leitner)10.00 – 11.00 Cross-linking Strategies I: Non-Cleavable Cross-linkers (Philip Andrews, Alexander Leitner)

11.00 – 11.30 Break

11.30 – 12.30 Cross-linking Strategies II: Cleavable Cross-Linkers (Lan Huang, Andrea Sinz)

12.30 – 14.00 Break
14.00 – 14.30 Cross-linking Harmonization Initiative
14.30 – 15.15 In Vivo Cross-linking experiments (Jim Bruce) 15.15 – 15.30 Break
15.30 – 16.30 Software MeroX (Michael Götze)
16.30 – 17.00 Cross-Linking Modeling (Alexander Leitner, Kostas Thalassinos, Nir Kalisman)

Goals of the Training School:

Protein-protein interactions are one of the main driving forces underlying all cellular processes and the knowledge of protein interfaces is the key to understanding cellular functions. Complementary to the classical methods of structural biology (X-ray crystallography,NMR spectroscopy and electron microscopy), cross-linking combined with mass spectrometry (MS) has developed into an alternative technique to obtain valuable information about the structure and dynamics of macromolecular assemblies in solution.

In this workshop, fundamentals of the cross-linking MS strategy will be introduced. Different cross-linking strategies using non-cleavable and MS- cleavable cross-linkers as well as in vivo cross-linking will be presented. Practical aspects of two complementary software tools (MeroX) and on modeling protein complexes based on cross-linking constraints will be taught. Participants are encouraged to bring their own laptop computers!

Please download the software here: http://www.stavrox.com/Download_MeroX_Win.htm

The training school is funded by the BMBS COST Action Program BM1403 “Native Mass Spectrometry and Related Methods for Structural Biology”

Postdoctoral fellow at University of Oslo

The Group for Structural Biology and Chromatin (Sekulic group) investigates chromatin biology and epigenetics with biochemical and structural approaches. The project aims at understanding changes in chromatin during mitosis and kinetochore formation. We use various biochemical and biophysical approaches (X-ray crystallography, SAXS, SANS, hydrogen-deuterium exchange coupled to MS …). In addition, we collaborate with cell biology groups to link structure with function.

A three-year position is available from August 2017. We seek highly motivated individuals with an excellent track record and experience in protein purification and biophysical and biochemical characterisation of proteins and protein complexes. Knowledge of chromatin and structural biology and mass spec techniques is an advantage. Recently, our group has obtained a funding for new HDX-MS instrument that is intended to be installed in the fall of 2017 and recruited candidate will help with establishing HDX-MS methods.  We offer stimulating environment with excellent working and social benefits.

Please submit your application through the web-based recruitment system linked here: http://uio.easycruit.com/vacancy/1789507/70932?iso=gb

Application deadline:  31.03.2017.

Best wishes,

Nikolina

Annual Research conference and MC meeting Heraklion, March 19-21

Cost_Crete_Logo

Draft programme

 

Sun 19th             

18:00                   Informal get-together in Heraklion (pre-dinner drinks)

20:00                  Informal dinner in Heraklion, self-organized

 

Mon 20th

9:30                    Coffee, IMBB FORTH

9:50-10:00        Welcome and introductory remarks
COST Chair, F. Sobott, University of Antwerp, Belgium
Local Organizer, M. Aivaliotis, IMBB Forth & University of Crete, Greece

10:00-10:30     Michael Kokkinidis
IMBB Forth & University of Crete, Greece

10:35-10:45    Session 1a introductory remarks
COST Vice-Chair, Sarah Cianferani, University of Strasbourg, France

10:45-11:05    Michal Sharon
Weizmann Institute, Israel

11:10-11:30   Nina Morgner
University of Frankfurt/M., Germany

11:35-11:55   Kostas Thalassinos

UCL London, UK

12:00-13:30   Lunch break & Posters

13:30-13:40  Session 1b introductory remarks
WG1 leader, Michal Sharon, Weizmann Institute, Israel

13:40-14:00  Michael Glocker
University of Rostock, Germany

14:05-14:20  Sneha Chatterjee
University of Antwerp, Belgium

14:25-14:45  Rita Grandori
University of Milano-Bicocca, Italy
14:50-15:05   Johannes Heidemann
Heinrich Pette Institut Hamburg, Germany

15:10-15:40   Coffee break

15:40-16:00   Edwin de Pauw
University of Liège, Belgium

16:05-16:25   Pol Ilag
University of Stockholm, Sweden

16:30-16:35   Daniel Driscoll
University College Cork, Ireland

16:40-17:20   Time for discussion (led by Sarah Cianferani & Michal Sharon)

18:30-19:30        Informal MC discussion (core group + interested MC members)

20:00              Conference (networking) dinner in Heraklion
Organized and paid by COST

Tue 21st

08:00            Formal MC meeting & vote on budget plan, IMBB Forth

10.00           Coffee, IMBB Forth

10:20-10:50   Nelson Barrera, Invited Speaker
Pontificia Universidad Católica, Santiago, Chile

10:55-11:20   Session 2a introductory remarks
Alex Leitner, ETH Zurich, Switzerland

11:20-11:40  Elien Vandermarliere

University of Gent, Belgium

11:45-12:00  Elodie Grifnee
University of Liège, Belgium

12:05-13:00 Lunch break & Posters

13:00-13:15  Session 2b introductory remarks
Kasper Rand, University of Copenhagen, Denmark

13:15-13:35  Jonathan Philips

University of Exeter, UK
13:40-13:55   Esben Trabjerg
University of Copenhagen, Denmark

14:00-14:20    Session 3 introductory remarks
Justin Benesch, University of Oxford, UK
14:20-14:35    SKYPE Perdita Barran
University of Manchester, UK
14:40-14:55    Jean Haler
University of Liège, Belgium

15:00-15:20   Marta Vilaseca
IRB Barcelona, Spain
15:25-16:00        Time for discussion (round table)

From 16:00         Free time!

 

Wed 22nd

Departure


 

For travel info please see the following site:

http://www.tavernarakislab.gr/local_info/141.html

 


 

Register for the meeting

Please log in to access the form

 

Postdoctoral Position at ETH Zurich / Chemistry

We seek to fill a postdoctoral position in our research group. The topic of the research project will be the coupling of a novel plasma ionization source for high-resolution mass spectrometry with solid-phase microextraction, characterization and further development of this hyphenated method, and development of promising analytical applications. This project is a collaboration with a major manufacturer and supplier of SPME and lab automation devices. State-of-the-art MS instrumentation is available in our group, and world-class departmental facilities (mechanical and electronic workshops, library services, computing facilities, etc.) are accessible at ETH Zurich.

Prerequisites: Ph.D. degree in chemistry or related area, strong background in analytical chemistry and instrumentation, motivated to work with an industrial partner. Further information: see http://www.zenobi.ethz.ch/research/ambient-mass-spectrometry.html. Starting date: January 2017, or upon mutual agreement.

Applications with CV, publication list, and 2 letters of recommendation should be sent directly to Prof. Renato Zenobi, by mid September 2016.

Postdoktoranden-Stelle, ETH Zürich / Chemie

In unserer Forschungsgruppe ist eine Postdoktorandenstelle neu zu besetzen. Das Forschungsthema betrifft die Kopplung einer neuartigen Plasma-Ionisationsquelle für die hochauflösende Massenspektrometrie mit Festphasen-Mikroextraktionsmethode, die Charakterisierung und Weiterentwicklung dieser gekoppelten Analysenmethode sowie die Entwicklung vielverprechender analytischer Anwendungen. Das Projekt ist eine Zusammenarbeit mit einem wichtigen Hersteller und Lieferanten von SPME Materialien und Laborautomations-Geräten.

Voraussetzungen: Abgeschlossenes Doktorat in Chemie oder einem verwandten Gebiet, sehr gute Kenntnisse in Analytischer Chemie, Freude an Instrumenten-Entwicklung und an einer Zusammenarbeit mit einem Industrie-Partner. Weitere Informationen unter http://www.zenobi.ethz.ch/research/ambient-mass-spectrometry.html. Beginn: Januar 2017 oder nach Vereinbarung.

Bewerbungen bis Mitte September 2016 mit CV, Publikationsliste, und 2 Empfehlungsschreiben direkt an Prof. Renato Zenobi

Postdoctoral Position at University of Liverpool

Have proteomics experience and interested in cell signalling/cancer research? A postdoc position is now available with Dr. Patrick Eyers and Prof. Claire Eyers (Centre for Proteome Research) at the University of Liverpool. Application deadline Friday 2nd September.

The laboratories of Dr Patrick Eyers and Professor Claire Eyers evaluate human phosphoproteomes using a variety of approaches, including biochemistry, transcriptomiccs, chemical biology and mass spectrometry. We are looking for an experienced cell signalling or MS-based phosphoproteomics researcher to lead a North West Cancer Research (NWCR) funded project to evaluate the Polo-like kinase 4 signalling pathway and its role in cancer. You will have a PhD in Biochemistry, Pharmacology or a related biological science, a strong interest in protein phosphorylation, and demonstrable knowledge and experience of mass spectrometry for cell signalling analysis. The post is available immediately for 1 year initially, with the possibility of a 2 year extension.

https://www.liverpool.ac.uk/working/jobvacancies/currentvacancies/research/001230/

Top Down and Structural Mass Spectrometry: a practical course

Lisbon | December 19-21, 2016

 

About

This course will cover many of the modern methods of structural analysis of bio-macromolecules by Mass Spectrometry.

Specific topics that will be addressed include:

  • Native Mass Spectrometry
  • Structural MS instrumentation
  • Top-down Mass Spectrometry

 

Details: http://structms2016.campus.ciencias.ulisboa.pt

Structural MS Workshop May 3-8, 2017

The David Lopatie Conference Centre, Weizmann Institute of Science, Rehovot, Israel

About the Workshop

Mass spectrometry (MS) is becoming increasingly popular in the eld of structural biology for analyzing protein structures and for mapping protein-protein interactions. Various MS-based approaches have been developed over the years to provide insights into the structural properties of protein complexes. Therefore, the aim of this workshop is to expose students and researchers interested in structural biology to the arsenal of tools o ered by structural mass spectrometry.

Registration deadline – February 15, 2017

Details: Structural MS Workshop

University of Bordeaux international post-doctoral program

The University of Bordeaux opened a competitive call for its international post-doctoral program (beginning of contract: July to December 2017).

Excellent candidates within 4 years of obtaining their PhD (+ parental leave conditions) are welcome to apply.

Call details: http://idex.u-bordeaux.fr/n/Talents/International-Post-Doctorates/r3137.html

The research project must be supported by a host lab in Bordeaux. My team is willing to support one candidate, with a project in the broad fields of structural mass spectrometry, nucleic acids structure, and/or non-covalent assemblies.

Call deadline: November 27th, 2016.

Interested candidates can email me a CV and a half-page project outline, preferably one month in advance of the call.

I would be grateful if you could forward this announcement to potential applicants.

 

Best regards,

 

Valérie Gabelica.

 

 

Dr. Valerie GABELICA
Research Director (DR2) – Team BiophyMS
ARNA Laboratory (Inserm U1212/CNRS UMR5320/Université de Bordeaux)
valerie.gabelica@inserm.fr
Tel. +33 (0)5 4000 2940
Institut Europeen de Chimie et Biologie

2, rue Robert Escarpit
33607 Pessac, France
www.iecb.u-bordeaux.fr/teams/GABELICA

 

Institute of Clinical Sciences RESEARCH ASSOCIATE

Institute of Clinical Sciences 
RESEARCH ASSOCIATE 
Salary range: £33,860- £42,830 per annum 

 
Applications are invited for a postdoctoral research position in the Reprogramming and Chromatin Group headed by Dr Petra Hajkova at the Clinical Sciences Centre (CSC) in Imperial College London. The group studies molecular mechanisms underlying epigenetic reprogramming in vivo and in vitro (for further information, please visit http://www.csc.mrc.ac.uk/Research/Groups/EDC/ReprogrammingChromatin/)
 
We are looking for an enthusiastic and passionate scientist experienced in the field of mass spectrometry to join our efforts to elucidate molecular mechanisms implicated in the dynamic changes in nucleic acid modifications observed in early mouse embryo, developing germ line and pluripotent stem cells. Our group operates our own QQQ LC/MS instrument (Agilent 6490) and focuses on cutting edge, ultra-sensitive detection of DNA and RNA modifications in minute biological samples (see Amouroux et al, Nat Cell Biol, 2016) .For informal enquiries please contact Dr Petra Hajkova (petra.hajkova@csc.mrc.ac.uk).